Sodium Channel Pan Antibodies

Target Information

Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV alpha subunits have been cloned and named NaV1.1-NaV1.9. The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9). Mammalian sodium channels are heterotrimers, composed of a central, pore-forming alpha subunit and two auxiliary beta subunits. The expression of the alpha subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain beta 1 through beta 4 subunits, whereas sodium channels in adult skeletal muscle have only the beta 1 subunit.

Synonyms

3-Feb; 6430408L10; A230052E19Rik; AI853486; alternative product; ataxia 3; B230332M13; BFIC3; BFIS3; BFNIS; brain III voltage-gated sodium channel; C630029C19Rik; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CDCD2; CERIII; CIAT; CMD1E; CMPD2; CMS16; CTC-264K15.6; dmu; EIEE11; EIEE13; EIEE6; ETHA; FEB3; FEB3A; FEB3B; FEPS2; FEPS3; FHM3; GEFSP2; GEFSP7; Gm1000; HB1; HB2; HBA; HBBD; HBSC II; HBSCI; HBSCII; HH1; hNa6/Scn8a voltage-gated sodium channel; hNaN; hNE-Na; HOKPP2; hPN3; HSAN2D; HSAN7; HYKPP; HYPP; ICCD; IVF; KIAA1356; Kiaa4197; LQT3; med; mH1; mH2; microI; mKIAA4197; mnd2; mnd-2; Mu-1; Na(v)1.2; Na(V)1.4; Na(V)1.8; Na+ channel; NAC1; NAC1A; NAC2; NAC3; naCh6; NachII; NaN; NaT; Nav1.1; Nav1.2; Nav1.3; Nav1.4; Nav1.5; Nav1.5c; Nav1.6; Nav1.7; Nav1.8; NaV1.9; Nbna1; NCHVS; NENA; NE-NA; Neuroendocrine sodium channel; nmf2; nmf335; nmf58; NSS2; nur14; Peripheral nerve protein type 4; peripheral nerve sodium channel 3; Peripheral nerve sodium channel 5; peripheral sodium channel 1; PFHB1; PN1; PN3; PN4; PN5; RII/RIIA; RIIA sodium channel protein; RNSCPIIR; SCAL; SCIII; SCN; SCN1; SCN10A; SCN11A; SCN12A; SCN1A; SCN2A; SCN2A1; SCN2A2; SCN3A; SCN4A; Scn5a; SCN8A; SCN9A; ScpII; seal; Sensory neuron sodium channel; sensory neuron sodium channel 2; SFNP; skeletal muscle sodium channel alpha subunit; skeletal muscle voltage-dependent sodium channel type IV alpha subunit; skM1; SkM2; SMEI; SNS; Sns2; SNS-2; sodium channel 25; sodium channel 6; sodium channel alpha-subunit; sodium channel protein brain I subunit alpha; Sodium channel protein brain II subunit alpha; sodium channel protein brain III subunit alpha; Sodium channel protein cardiac muscle subunit alpha; sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type 1 subunit alpha; sodium channel protein type 10 subunit alpha; Sodium channel protein type 11 subunit alpha; sodium channel protein type 2 subunit alpha; Sodium channel protein type 3 subunit alpha; sodium channel protein type 4 subunit alpha; Sodium channel protein type 5 subunit alpha; sodium channel protein type 8 subunit alpha; Sodium channel protein type 9 subunit alpha; sodium channel protein type I subunit alpha; Sodium channel protein type II subunit alpha; sodium channel protein type III subunit alpha; Sodium channel protein type IV subunit alpha; sodium channel protein type IX subunit alpha; Sodium channel protein type V subunit alpha; sodium channel protein type VIII subunit alpha; Sodium channel protein type X subunit alpha; sodium channel protein type XI subunit alpha; sodium channel protein, brain I alpha subunit; sodium channel protein, brain I subunit alpha; sodium channel protein, brain II subunit alpha; sodium channel protein, brain III subunit alpha; sodium channel protein, brain type 2 alpha subunit; sodium channel type X alpha polypeptide; sodium channel voltage gated type 1 alpha subunit; sodium channel voltage-gated type 11 alpha polypeptide; sodium channel voltage-gated type 4 alpha polypeptide; sodium channel voltage-gated type I alpha polypeptide; sodium channel voltage-gated type II alpha polypeptide; Sodium channel voltage-gated type IV alpha polypeptide; sodium channel voltage-gated type V alpha polypeptide; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel voltage-gated type X alpha polypeptide; sodium channel voltage-gated type XI alpha polypeptide; sodium channel, voltage gated, type I alpha subunit; sodium channel, voltage gated, type II alpha subunit; sodium channel, voltage gated, type III alpha subunit; sodium channel, voltage gated, type IV alpha subunit; sodium channel, voltage gated, type IX alpha subunit; sodium channel, voltage gated, type V alpha subunit; sodium channel, voltage gated, type VIII alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage gated, type X alpha subunit; sodium channel, voltage gated, type XI alpha subunit